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This is because telomerase production significantly falls with time

This decline is one of the mechanisms behind the fatigue, cognitive slowing, and reduced physical resilience that patients often attribute to just getting older. A comprehensive review published in Cell Metabolism documenting the age-related decline in NAD levels and the downstream effects on mitochondrial function, cellular repair, and energy metabolism across tissue types

it simply suggests that rigorous testing has to be done before it could be approved for wide spread use in humans as a standard of care for the treatment of intended diseases

Larger sample sizes along with functional validation will be needed to further implicate these germline variants in lung cancer pathogenesis, although these early studies in individuals who have never smoked have highlighted the presence of pathogenic alterations with large effect sizes in DNA repair-related genes

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